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The drug's US manufacturer has asked UK distributors to stop taking orders from pharmacies until next month's price increase.

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A prespecified analysis of the SELECT trial revealed that patients assigned to once-weekly subcutaneous semaglutide 2.4mg lost significantly more weight than those receiving placebo and showed improvements in various anthropometric indices.

Our functional and structural data suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy

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