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For example, optimal levels of both diet and exercise increases bone mineralization during childhood, a critical period of growth and development, and this lessens their risk of osteoporosis and bone fractures later in life

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Role of alpha-cell GLP-1 production in metabolic dysfunction Alpha-cell GLP-1 production as an adaptive response to metabolic dysfunction Although the in vivo physiological function of intra-islet GLP-1 has been questioned since levels of GLP-1 in the pancreas of healthy mice are considerably low and sometimes undetected (83), metabolic stress has been reported to potently increase alpha-cell-derived GLP-1 and decrease L-cell-derived GLP-1 in rodents and humans (58, 8490)

The protocol is available at The Research Question What is the scope of published evidence on the effect of using GLP1-RAs and SGLT2is in people with T2D