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In elderly patients with stage 3 CKD, there was no effect of MRA on CV outcomes, potentially because two-thirds of patients stopped spironolactone treatment within 6 months predominantly because they met safety stopping rules (21)
Among adults with overweight or obesity without diabetes, once-weekly subcutaneous semaglutide compared with once daily subcutaneous liraglutide, added to counseling for diet and physical activity, resulted in significantly greater weight loss at 68 weeks
All three studied doses (4 mg, 9 mg, and 12 mg) met the primary and key secondary endpoints
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2019 Oct;7(10):776-85
It mimics the action of natural GLP-1 , a hormone released in the gut after eating
