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The SUSTAIN 6 cardiovascular outcomes trial demonstrated that semaglutide significantly reduced the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes at high cardiovascular risk, many of whom were taking metformin as background therapy

Overall pipeline momentum is unprecedented for metabolic disease

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A previous study reported that GLP-1Rs are observed in brain regions related to energy balance and regulation of moods, such as the amygdala, hippocampus, and dorsal raphe nucleus (Merchenthaler et al., 1999)

Phase 3: Ongoing, comparing retatrutide with placebo for long-term safety and effectiveness in large groups