difference between glp 1 and gip GLP-1 vs. GLP-1 + GIP: What's the for your Metabolism? Beyond glycemia: Comparing tirzepatide to
Description
Determining the true incidence of gastroparesis associated with GLP-1 receptor agonist use presents significant methodologic challenges

In trials, medication treatments may be more standardized and less influenced by sociocultural variables than lifestyle and surgical interventions

For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

But there are some natural alternatives to help support appetite control, blood sugar, and metabolism
Kidney Int Rep 2:251260 Foster MC, Hwang S-J, Porter SA, Massaro JM, Hoffmann U, Fox CS (2011) Fatty kidney, hypertension, and chronic kidney disease

So that adaptation is real, occurs, and we want to be able to have tricks to go around