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GLP-1R is expressed in intestinal intraepithelial lymphocytes, and the GLP-1R agonist exendin-4 significantly inhibits inflammatory cytokines and macrophage infiltration (59)

Discussion The clinical management of patients with type 2 diabetes has to balance the potential benefits of controlling hyperglycemia on microvascular and macrovascular complications, [11] with possible side effects of treatment and possible harm from over intensive control of glycemia

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Por otra parte, el GLP-1 circulante penetra en reas circunventriculares del SNC como el rgano subfornical, rgano vasculosum de la lmina terminalis, la eminencia media prxima al ncleo arcuato y el rea postrema, merced a la permeabilidad parcial de la barrera hematoenceflica2,3,6

These medications help lower blood sugar, promote weight loss, and improve insulin sensitivity
