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Targeting Dementia and Metabolic Disease With Cannabis and Cannabidiol Both cognitive neurodegenerative disorders, such as AD, and metabolic disease that includes DM are chronic progressive disorders that call for innovative therapies to address the intimate link between these disease entities

Multiple large-scale observational studies and peer-reviewed analyses published in 2025 and 2026 have contributed substantially to this field

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For instance, semaglutide users face a relative risk of 2.10 for constipation compared to placebo, while tirzepatide users have an even higher relative risk of 3.36

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The combination of psyllium and magnesium citrate addresses constipation from two different mechanisms: psyllium adds bulk and holds water in the stool, while magnesium draws additional water into the intestine through osmosis