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[PubMed] [Google Scholar] 350.Vrang N., Phifer C.B., Corkern M.M., Berthoud H.R

Prescription GLP-1 receptor agonist medications have received significant attention following clinical trial outcomes

In addition to providing a pharmacokinetic profile that enables once-weekly dosing, the acylation moiety of tirzepatide also contributes to the interaction with both the GIPR and GLP-1R, as well as possibly the cell membrane 50

A previous meta-analysis of randomized clinical trials suggested a differential effect of each DPP4i on the risk of HF [103]

Obesity is also a leading driver of gastrointestinal (GI) and hepatobiliary cancers, from colorectal cancer to hepatocellular carcinoma, making any therapy that modifies obesity-related cancer risk directly relevant to gastroenterology practice

Second, magnesium has a modest effect on blood pressure and may potentiate the effects of antihypertensive medications
