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We proposed that the insulinotropic effect of this GLP-1R agonist (GLP-1RA) would synergize with the insulin-sensitizing effect of tesaglitazar to optimize glucose handling, while the body weight lowering effect of the GLP-1RA would buffer against any potential obesogenic activity of PPAR agonism

In NK cell-depleted mouse models, neutrophils tend to adopt the N2 phenotype, characterized by upregulated VEGF-A expression, thereby promoting tumor growth and angiogenesis (119)