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On the other hand, the most abundant DPP-IV-processed metabolite GLP-1 (9-36) NH2 , has also been reported to have biological activities, protecting human aortic endothelial cells and cardiomyocytes in vivo in dogs (137) and ex vivo in mice (138) and rats (139), even in the absence of a GLP-1 Receptor (140, 139)

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