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Enhances insulin secretion, protects metabolic health, and works synergistically with GLP-1 to minimize common gastrointestinal side effects

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Objective This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework

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Randomized participants follow an 8-week dose escalation regimen (3 mg [weeks 04], 7 mg [weeks 48], and 14 mg [weeks 8156])

Obesity is the fifth leading risk factor for global deaths with numbers continuing to increase worldwide