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Conversely, Dpp4 Gut/ mice demonstrate an increase in postprandial TG excursion, notably under high-fat diet conditions

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Trials are monitoring whether Retatrutide increases incidence beyond baseline

Selected Research Wilding JPH, et al

Kidney Medicine describes two patients with diabetic kidney disease who rapidly declined after taking GLP-1 drugs

In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [5-, 17-, and 59-fold the maximum recommended human dose (MRHD) of 1 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (2-, 5-, and 17-fold MRHD) were administered to the females