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This mechanism would bypass the gastrointestinal tract and provide steady-state drug levels over an extended period

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however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development

The placebo group lost 2.4%

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The truth is, once the medication stops, the weight will likely creep back on if nothing else changes (as seen in studies)