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Understanding which patients are candidates for GLP-1RAs treatment will be key, according to Lorenzo Leggio, MD, PhD, clinical director of the National Institute on Drug Abuse

Because GLP-1 is quickly broken down by enzymes like DPP-4, only a small fraction remains active

Some of the new predictors (Tier 3), such as REG1A and GP2 and certain radiomic features, may improve classification within certain research contexts, but are not essential for the routine diagnosis of PDM

3ac and Extended Data Fig

This pattern may accelerate age-related muscle loss and increase risk for functional impairment and disability

81% of patients receiving semaglutide achieved HbA1c levels below 5.7%, versus 19% in the placebo group