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Funding This work was partially supported by National Institutes of Health NORC Center Grants P30DK072476, Pennington/Louisiana, P30DK040561, Harvard, and R01DK109008, Shape UP

GLP-1 receptor agonists are medications designed to mimic the effects of natural GLP-1

Also, these medicines have been shown to be safe in many clinical trials

To further substantiate this local release, we performed ex vivo experiments and measured the amount of GLP-1 present in the supernatant of OB explants from RD and WD mice

But the GLP-1s have now been studied in a number of very nice randomized control trials specifically targeting this issue

GLP-1 has recently been shown to regulate autophagy in beta cells 51,52