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Unexpected benefits for kidney and liver disease turned up in the diabetes trials, too

10.1016/j.jamcollsurg.2021.03.002 96 SchaverienM
Eli Lilly has pursued civil lawsuits against numerous compounding operations, resulting in court injunctions shutting down several facilities

GLP-1 is known to acutely induce glucose competence in -cells, both in isolated islets and in human subjects 31, 32

Whether retatrutide's additional glucagon and GIP receptor activity confers further hormonal benefits remains to be established in dedicated studies

These findings suggest that these compounds diminish the incentive salience of drug-related cues, affecting the wanting component without necessarily eliminating direct pleasure