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This extra fluid can collect in your body, making you feel bloated or puffy

In DUAL-2, the A1c reductions were significantly different across the subgroups of baseline treatment

Beyond glucose lowering and weight reduction, GLP-1based therapies exert multiple mechanistic effects that directly target the pathophysiology of MASLD/MASH: Reduction of hepatic de novo lipogenesis Improvement in insulin sensitivity Suppression of hepatic glucose production Reduction in visceral and ectopic fat accumulation Enhancement of mitochondrial function and fatty acid oxidation Anti-inflammatory signaling with decreased cytokine activation Potential attenuation of hepatocellular injury and fibrosis progression Importantly, the benefits of GLP-1 therapies appear to extend beyond simple weight loss alone

KFF Health Tracking Poll May 2024: The Public's Use and Views of GLP1 Drugs