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Possible side effects and risks In phase 1 clinical trials , the most common side effects of retatrutide were nausea/vomiting (feeling or being sick) or bloating
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In contrast, consider a peptide with a 168-h half-life (like semaglutide)
83 , 84 Nonetheless, product labeling for GLP-1 RAs advises monitoring volume status, especially in patients with fluid loss or concurrent antihypertensive use
Exercise also fails to help in most cases, as burning calories is a slow and painful process
While semaglutide offers profound therapeutic benefits, it is not a universally perfect fit for every individual
