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Glucose-induced Translational Control of Proinsulin Biosynthesis Is Proportional to Preproinsulin mRNA Levels in Islet -Cells but Not Regulated via a Positive Feedback of Secreted Insulin

Suggesting that GLP-1 drugs influence broader metabolic processes

( B ) Representative Western blot and quantitative densitometric analysis of 83-kDa MTP protein expression in lysates from caSMCs transfected with MTP siRNA, control siRNA, or no siRNA

Although a second application of CNO failed to induce a second increase in Ca 2+ in half of the responsive ND neurons, in ND neurons that exhibited a second response to CNO, PPADS reduced the peak area of the CNO-induced Ca 2+ rise by 53%, supporting the idea of ATP-mediated signalling from GLUTag cells to neurons (Fig

Recent Mergers & Acquisitions (M & A) 2025-2026: Mar 2026: BioMarin Pharmaceutical agreed to acquire rare disease biotech Amicus Therapeutics for $4.8B, strengthening metabolic & rare disease franchise overlap with diabetes-associated disorders Mar 2026: Sanofi entered $2.2B acquisition deal for Dynavax Technologies to expand vaccine and immunometabolic pipeline supporting diabetes-comorbidity therapeutics Jan 2026: Eli Lilly and Company announced acquisition of Ventyx Biosciences for $1.2B, expanding cardiometabolic and diabetes-related pipeline into immunology-linked therapies 2026 (closed/announced): Merck & Co

GLP-1RAs, such as liraglutide and exenatide, attenuate RAGE expression in several cell types, especially under diabetic conditions (Zhang et al., 2016