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Description
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Deane AM, et al
Lancet 402 , 429431 (2023)
Exposures Two cohorts were assembled, with the first composed of patients who started and continued on GLP-1 receptor agonists or DPP-4 inhibitors between 1 January 2007 and 31 December 2020 and the second composed of patients who started and continued on GLP-1 receptor agonists or SGLT-2 inhibitors between 1 January 1 2013 and 31 December 2020
Genetic biomarkersparticularly GLP1R and GIPR variantsmay help contextualize whether a patient is likely to benefit from dual-agonist strategies like tirzepatide or GLP-Squared, supporting more targeted provider conversations
The enrollment process begins with a brief telehealth consultation where a provider reviews your medical history, current medications, and weight loss goalstypically completed within 24 hours
