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Description
Weight Loss Plateau on Semaglutide Semaglutide (Wegovy) produces an average of 14.9% body weight loss at 68 weeks on the 2.4mg maximum dose, per the STEP 1 trial (Wilding et al., NEJM 2021)

39 In the arcuate hypothalamic nucleus, activation of GLP-1 RAs stimulates pro-opiomelanocortin neurons, promoting satiety through -melanocyte-stimulating hormone and inhibiting hunger-associated neurons expressing neuropeptide Y and agouti-related peptide

It then slows down your digestive processes

H., Kwon, J., Nan, B., & Reikes, A

Semaglutide starts working immediately after the first dose, as it begins mimicking the GLP-1 hormone

While the absolute risk remains uncertain, the potential severity of aspiration has prompted precautionary approaches
