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Exploring serotonergic therapies for weight-loss: progress, challenges, and future directions Given the extensive communications of the neural 5-HT system with brain regions involved in regulating feeding behavior and body weight homeostasis, it represents a promising target for therapeutic interventions aimed at alleviating obesity

In a March 18 filing, they argue that the drug makers exaggerated the benefits of GLP-1 medications while downplaying serious gastrointestinal risks, such as gastroparesis and intestinal blockages

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on the other hand, Akt signaling downregulates the expression of myostatin by inhibiting the binding of NF-B to the myostatin promoter

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