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Meanwhile, GLP-1RAs showed a trend towards a reduced risk for nine respiratory diseases, although not reaching statistical significance, including pneumonia (RR 0.89, 95% CI 0.781.00, p = 0.05
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In this Review, we summarize current preclinical and clinical evidence, showing that the riskbenefit profile of GLP1RAs remains favourable in individuals with T2DM and obesity, although caution is warranted in those with a low cardiometabolic risk, for whom the potential risks of cancer might outweigh any expected benefits

E., Crowell, M

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Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

GLP-1-based therapies, such as GLP-1 receptor agonists, glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors, improve glucose control through various mechanisms including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake
