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Description
Particularly, it determined the upregulation of ROS-scavenging enzymes, anti-inflammatory cytokines, (IL-10, IL-6 and PPAR ), tight junctions proteins, such as ZO-1, MUC-2, claudin-3, and the downregulation of inflammatory genes (TNF-, IL-1) [14]
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In the dose titration study, from mean baseline body weight of 81.5 kg, after randomization there was a mean reduction of 1.33 kg in the SYMLIN treatment group compared to a mean increase of +1.25 kg in the placebo treatment group
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Individual response varies significantly, with some patients achieving minimal weight reduction even with adherence
