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The development costs were lower, generic competition is now available, and the manufacturing process for oral medications is simpler than producing injectable biologics

Knudsens work found that liraglutide was internalized by proopiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART) neurons and indirectly inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons through Gamma Amino Butyric Acid (GABA) dependent signaling

T2DM patients experienced a 15% reduction in their IL-6 levels after taking liraglutide [28]

Results are expressed as the mean SEM

Given the pathogenic association between insulin resistance and MASLD, and overlap with obesity and type 2 diabetes, glucose-lowering agents targeting insulin resistance, adipose tissue dysfunction, and the incretin system have been studied for treatment of MASLD/MASH [11]

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