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To date, over 150 pathogenic variants have been identified in the MC4R gene, including missense, nonsense, and frameshift mutations

The STEP 3 trial demonstrated that combining semaglutide with intensive behavioral therapy (structured dietary counseling, physical activity prescription, and cognitive behavioral strategies) produced greater weight loss (16.0%) than semaglutide with standard counseling alone

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Abbreviations: BBR: Berberine, DBP: diastolic blood pressure, HTN: Hypertension, SBP: Systolic blood pressure

The result is a smaller but still poorly composed body