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111 CBD has been shown to intensify A 2A receptor signaling by inhibiting cell renewal of an adenosine transporter, generating anti-inflammatory and antioxidant effects (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 321.Lee CMY, Woodward M, Colagiuri S

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Accordingly, the areas of unmet need for new treatments are reflected in the lesions that underly the hyperglycaemia, notably impaired function and number of pancreatic beta cells, insulin resistance and glucose toxicity, which are frequently aggravated by excess adiposity, abnormalities of glucagon secretion, an altered incretin response and disturbances in lipid metabolism [6]