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Medications like semaglutide, tirzepatide, liraglutide, and others are defined as GLP-1 meds, and they've revolutionized weight reduction

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The remarkable commercial success of GLP-1 receptor agonists is fueling investment, accelerating science, and creating new analytical challenges

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Here, we report three cryo-electron microscopy structures of GLP-1R bound to (i) compound 2 (an ago-allosteric modulator)