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Percentages are rounded up to one decimal place BID two times a day, BMI body mass index, BMOD intensive behavior modification, GLP-1RA glucagon-like peptide 1 receptor agonist, IBT intensive behavioral therapy, NR not reported, OAD oral antihyperglycemic drug, PT phentermine-topiramate, QD once-daily, TID three times per day a Based on patients achieving 5% weight loss during the run-in period b NB16: sustained-release naltrexone 16 mg per day plus sustained-release bupropion 360 mg per day combined in fixed-dose tablets