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Semaglutide was removed in February 2025

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Glucagon-like peptide-1 (GLP-1) agonists are very popular and useful medications for the treatment of type 2 diabetes mellitus and obesity

However, there was progress in the UK where the government announced Scotland CardioMetabolic Impact Study (SCoMIS) , a pioneering Real-World study, which will provide Wegovy to between 3,000-5,000 people living with Obesity in Scotlands poorest areas free of charge during a three year study [11] Despite FDA phasing out enforcement discretion that allowed GLP-1 compounding during shortages - and setting May 2025 deadlines for compounding to cease - compounding has continued beyond this deadline [12]

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Purpose of Review This review summarizes the current understanding of the physiologic influence of GLP-1 RAs on gastrointestinal motility, highlights key clinical implications of these effects, and defines areas for future investigation