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Can GLP-1 analogues be used for weight loss without having diabetes

Glycemic Control# Liraglutide (LEAD Program)# LEAD trials demonstrated HbA1c reductions of 1.0-1.5% at 1.2-1.8 mg daily Victoza approved for T2D at max 1.8 mg daily Effective monotherapy and combination therapy for glucose control Tirzepatide (SURPASS Program)# SURPASS-1 (monotherapy): HbA1c reduction of 2.07% at 15 mg over 40 weeks SURPASS-2 (vs semaglutide 1.0 mg): Superior HbA1c reduction (2.46% vs 1.86%) Up to 2.58% HbA1c reduction across SURPASS trials Tirzepatide's dual incretin mechanism provides markedly superior glycemic control, driven by additive insulin-sensitizing and insulinotropic effects from both receptor pathways

In-person and telehealth options both work, though remote programs should still include lab review and a plan for an in-office exam when needed

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Allison Rhodes, MD, an obesity medicine specialist at Ohio State, describes how important this is and how she personally strives to provide a safe space for patients