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In STEP 1-3 clinical trials, a weekly dose of 2.4 mg semaglutide resulted in a 49% reduction in C-reactive protein (CRP) levels, while a 1 mg weekly dose led to a 42% decrease, compared to placebo after 68 weeks

If these therapies become easier to use, monitoring becomes even more important

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This knowledge informs whether continuous therapy is essential or whether structured maintenance protocols might suffice

Eli Lilly is expected to submit for FDA approval in late 2026, with potential U.S