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Insulin resistance promotes Parkinsons disease through aberrant expression of -synuclein, mitochondrial dysfunction, and deregulation of the polo-like kinase 2 signaling

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In Gipr fl/fl mice, dulaglutidevehicle treatment resulted in significant reductions in body weight compared to vehiclevehicle treatment (Fig

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If gastrointestinal side effects are intolerable despite optimal management, discontinuation may be appropriate, and your healthcare team can discuss alternative treatment options

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Timeline comparison: Standard microdosing: 20-32 weeks to maintenance Accelerated: 12-20 weeks to maintenance Savings example: Slow (24 months): $7,200 total Moderate (16 months): $4,800 total Saves: $2,400 Don't rush past tolerable side effects

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