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Biol Psychiatry Cogn Neurosci Neuroimaging

Physiology of incretins in health and disease

[DOI] [PubMed] [Google Scholar] 342.Yegen B.C., Gurbuz V., Coskun T., Bozkurt A., Kurtel H., Alican I

This triple engagement distinguishes retatrutide from GLP-1 monoagonists like semaglutide or dual agonists like tirzepatide, potentially amplifying metabolic benefits across multiple organ systems including liver, pancreas, and central nervous appetite centers

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6 Within the kidneys, GLP-1 receptors are predominantly located in the proximal tubule, where they modulate sodium reabsorption and contribute to natriuresis