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Metabolic disorders, particularly type 2 diabetes mellitus (T2DM) and obesity, contribute significantly to this burden, affecting over 460 million people worldwide with diabetes and creating a substantial interplay between metabolic and cardiovascular pathophysiology [1,2]

Biosimilar pipelines will accelerate after semaglutides Brazilian patent expiry in March 2026, as Fiocruz-EMS aims for 2 million annual pens by 2028

Efficacy and safety of the once-weekly GLP-1 receptor agonist albiglutide versus sitagliptin in patients with type 2 diabetes and renal impairment: a randomized phase III study

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They also tend to improve fertility either by increasing LH surge in hypothalamus-pituitary inhibition due to estrogen excess connected with obesity or decreasing too high LH levels accompanying hyperinsulinemia