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The number of studies examining newer medicines like semaglutide and tirzepatide remains relatively small, and follow-up durations after stopping medicines were generally short, meaning some estimates are modelled projections beyond observed follow-up

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21 Remarkably, even in HF-free patients with morbid obesity, cardiac abnormalities can be seen that are consistent with left ventricular (LV) remodelling and dysfunction, including greater LV mass, LV diastolic dysfunction and elevated LV filling pressure

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