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Understand the mechanism of action, the expected timeline, the potential side effects, and the contraindications

Most side effects, such as nausea, diarrhea, and constipation, appear dose-dependent

Clin Pharmacol Ther 88:801808 Napolitano A, Miller S, Nicholls AW et al (2014) Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus

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