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Figure 3 shows the timeline tracking major therapeutic milestones in HFpEF management, from early therapies (beta-blockers, angiotensin-converting enzyme inhibitors (ACEi)) to recent advances (sodium-glucose cotransporter-2 inhibitors (SGLT2i), semaglutide)

New data out of ESC Congress 2025 suggest care teams can take a more minimalist approach during a majority of TAVR cases and only treat patients with local anesthesia