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There were two other dual agonists whose sequence has been reported so far, Tyr 1 has been used in MAR709 (designed by Finan et al in 2013, described by numerous other names: DA5-CH, DA-JC1, NNC0090-2746, RG7697, etc.) and His 1 has been used in CY-5 (Figure 3)

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The CANVAS trial confirmed the same result with the use of canagliflozin [103], as did the DECLARE TIMI trial where dapagliflozin was used [104]