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Losing 10% to 15% of your body weight triggers your body to increase hunger hormones and decrease satiety signals, pushing back against further weight reduction

Estimated mean changes in HbA 1c from baseline to week 26 were 9 mmol/mol, 14 mmol/mol and 17 mmol/mol (0.8 percentage points, 1.3 percentage points and 1.6 percentage points) for oral semaglutide 3 mg, 7 mg and 14 mg, respectively, and 7 mmol/mol (0.6 percentage points) for sitagliptin 100 mg (Fig

NICE guidance (NG28) recommends GLP-1 receptor agonists as a treatment option for adults with type 2 diabetes when: Triple therapy with metformin and two other oral drugs is not effective, not tolerated or contraindicated The person has a BMI of 35 kg/m or higher (adjust accordingly for people from particular ethnic groups) and specific psychological or other medical problems associated with obesity The person has a BMI lower than 35 kg/m and insulin would have significant occupational implications, or weight loss would benefit other significant obesity-related comorbidities GLP-1 receptor agonists may also be considered in combination with insulin therapy in specialist care settings Beyond glycaemic control, specific GLP-1 receptor agonists offer significant cardiovascular benefits

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No downtime is needed, allowing patients to continue daily activities immediately after treatment
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