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[DOI] [PubMed] [Google Scholar] [39].Tamborlane WV, Barrientos-Perez M, Fainberg U, Frimer-Larsen H, Hafez M, Hale PM, et al

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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025

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Severe Nutritional Deficiencies If your leg pain is accompanied by extreme weakness, numbness, or a pins and needles sensation, you may have a significant vitamin deficiency (such as Vitamin B12) or a neurological issue

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