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CKD affects approximately 37 million adults in the US and is a common complication of diabetes, with approximately 40% of people with type 2 going on to develop the condition

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Disclosure The authors declare no competing interests

In a recent study examining the ability of single and dual incretin receptor agonists, exendin-4, lixisenatide, Peptide 17, DA3-CH and DA-JC4 had significant rates of blood-to-brain influx, but liraglutide, semaglutide and Peptide 18 did not measurably cross the BBB

They compared GLP-1 RA users and non-users to evaluate the risk of developing acute pancreatitis

Madsbad et al