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This is a built-in safety mechanism that distinguishes GLP-1 receptor agonists from older diabetes medications

After this period, it must be discarded, as it might no longer be free of germs

Practical timing considerations include ensuring patients can commit to weekly injections and follow-up appointments, verifying insurance coverage or discussing out-of-pocket costs before initiation, scheduling initiation when patients can manage potential gastrointestinal side effects (avoiding major life events, travel, or work commitments in the first 4-8 weeks), and confirming patients are not planning pregnancy in the near term

Be sure to submit your re-enrollment application before your enrollment expires to continue receiving medications

Acknowledgements The authors thank our lab members for their cooperation throughout this study