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however, this impairment is lost in low-fat dietfeeding conditions (9, 104)

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(2021) of the CVOTs found that the GLP-1 RAs are associated with a significant 14% relative risk reduction in terms of major adverse cardiovascular events (MACE, a standard 3-component composite endpoint) (hazard ratio [HR] 0.86

Some individuals also report using microdoses for appetite modulation without seeking the substantial weight loss associated with higher doses, or as a gentler introduction to the medication before escalating to standard doses

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