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Efficacy analyses were performed in the full analysis population (all participants who had undergone randomization) according to the intention-to-treat principle

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Tirzepatides association with reduced cataract incidence represents a notable finding, given sparse evidence for GLP-1 RA effects on cataract formation in people with obesity

3 Visceral fat is among the most potent risk factors for developing HFpEF and is associated with mechanical disruption of splanchnic circulation, venoconstriction, decreased systemic vascular resistance, steatosis, increased aldosterone levels, hypertension and increased stressed blood volume