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To prevent evidence updates from lagging behind clinical practice, this review proposes a Learning Health System (LHS) objective: iteratively updating risk stratification and decision support through continuous real-world data streams rather than relying on static conclusions

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Bianca Itariu: declares no conflict of interest relevant to this study

Approach to treatment failure in inflammatory bowel disease

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

Some less common side effects worth discussing include anxiety , insomnia , sleep disruption , and dizziness