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Patients with heart failure in whom SGLT2 inhibitors cannot be given are also a group recommended for GLP-1 analogue treatment

This strategy involves administering smaller-than-standard doses to harness the metabolic and protective benefits of GLP-1 activation while minimizing side effects, cost, and rapid weight loss

Marchese A, Paing MM, Temple BR, Trejo J

As previously reported, their effect on MACE goes beyond glycaemic control: the reduction of atherosclerotic plaque formation, regardless HbA1c reduction, was confirmed by different studies on liraglutide and semaglutide

Risk factors include kidney problems, liver impairment, age over 65, heart failure, and heavy alcohol use