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On April 1, 2026, the FDA issued further clarification reminding 503A pharmacies that compounded semaglutide combined with additional ingredients may still be considered essentially a copy of an FDA-approved product depending on route of administration and strength, and that individual clinical justification must be documented

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Furthermore, as shown by Salamun, procedures assessing short-term, preconception GLP-1RA exposure prior to IVF cycles require comprehensive validation, as they may function as an efficacious metabolic-priming technique to improve ovarian response and endometrial receptivity [28]