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Testosterone replacement therapy (TRT) works by restoring hormone levels to normal ranges, which can modestly improve metabolic function and lean muscle preservation

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This means that visual inspection is a useful but incomplete tool

PIONEER 5 and 8 also showed efficacy and safety of oral semaglutide as a second- and third-line drug.[15,16,17,18,19,20,21,22,30,31] Thus, oral semaglutide can be used across the spectrum of diabetes as a first-, second- and third-line drug

Moreover, oral semaglutide improves systolic blood pressure, with superior reduction compared with placebo and sitagliptin [35, 37, 40, 42], adding an extra contribution to reduce cardiovascular risk

Finally, 4,052 BC patients with T2D were included to compare GLP-1RAs to SGLT2 inhibitors