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Common reasons include: Weight loss plateaus Online misinformation or social media trends Misunderstanding how the medications work In most cases, providers recommend adjusting the treatment plan instead of combining medications

It has been proven that pancreatic islets have circadian genes such as CLOCK and BMAL1 in Homo sapiens and rodents (119, 120), and disruption of circadian genes leads to diabetes (121)

It is the only non-surgical anti obesity drug to be endorsed in this capacity

In early 2023, the American Academy of Pediatrics recommended that children and teens with obesity be evaluated early and treated aggressively, including with surgery and medication if warranted

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Renal Function : Both Januvia and metformin are primarily excreted by the kidneys, so their use may require adjustments in patients with impaired renal function
